PROTEOMIC ANALYSIS OF THE TREPONEMA PALLIDUM SUBSP. PALLIDUM SS14 STRAIN: COVERAGE AND COMPARISON WITH THE NICHOLS STRAIN PROTEOME

Proteomic analysis of the Treponema pallidum subsp. pallidum SS14 strain: coverage and comparison with the Nichols strain proteome

IntroductionStrains of the syphilis spirochete, Treponema pallidum ssp.pallidum, group into one of two deep-branching clades: the Nichols clade or the globally dominant Street Strain 14 (SS14) clade.To date, in-depth proteome-wide analyses have focused on Nichols clade strains.MethodsThe T.pallidum SS14 clade reference strain (SS14) proteome was ch

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Instrumental neutron activation analysis (INAA) and liquid chromatography (LC) coupled to high resolution mass spectrometry (HRMS) characterisation of sildenafil based products seized on the Italian illegal market

The commerce of illegal and copyright medicinal products on internet is a serious criminal problem.Drugs for erectile dysfunction such as phosphodiesterase type 5 inhibitor are the most commonly counterfeited medicines in Europe.The search of possible toxic chemical substances in seized products is needed.Moreover, the profiling of the material can

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